Waldenstrom Macroglobulinemia
Here you will get an overview of the pathology, the ability to treat diseases with Oriental medicine, and with acupressure therapies along with other therapies combined.
The information is updated gradually and regularly. For reference only, not a substitute for your doctor.
Waldenstrom Macroglobulinemia (WM), also known as lymphoplasmacytic lymphoma, is a rare form of cancer that affects the blood and bone marrow. WM is characterized by the overproduction of an abnormal protein called macroglobulin, which can thicken the blood and interfere with its ability to flow through blood vessels. While there is no known cure for WM, early diagnosis and treatment can help manage symptoms and improve quality of life for patients.
Causes and Risk Factors:
The exact cause of WM is unknown. However, researchers believe that genetic mutations may play a role in the development of this condition. WM is most commonly diagnosed in older adults, with the average age at diagnosis being 65 years old. Additionally, men are twice as likely to develop WM as women.
Symptoms:
The symptoms of WM can vary depending on the individual, but common signs include fatigue, weakness, weight loss, and fever. As the disease progresses, patients may also experience symptoms related to anemia, such as shortness of breath, dizziness, and pale skin. Other potential symptoms include enlarged lymph nodes, abdominal pain, and neurological issues such as numbness or tingling in the extremities.
Complications:
Complications of WM can include hyperviscosity syndrome, a condition where the thickening of the blood caused by excess macroglobulin can lead to impaired circulation, vision problems, and even strokes. Additionally, WM can lead to a weakened immune system, making patients more susceptible to infections.
Prevention and Treatment:
There are currently no known ways to prevent WM. However, early diagnosis and treatment can help manage symptoms and improve quality of life for patients. Treatment options for WM typically involve chemotherapy, radiation therapy, or targeted drug therapies. In some cases, a stem cell transplant may be necessary.
Oriental Medicine:
While there is limited research on the use of Oriental medicine to treat WM specifically, acupuncture and acupressure may be beneficial for managing symptoms associated with this condition. Acupuncture is a traditional Chinese medicine technique that involves the insertion of thin needles into specific points on the body. Acupressure is a similar technique that uses pressure instead of needles. Both techniques have been shown to help manage pain, fatigue, and stress in cancer patients.
In a study published in the Journal of Pain and Symptom Management, researchers found that acupuncture was effective in reducing pain and fatigue in patients with lymphoma. Additionally, a review of several studies on acupuncture and cancer-related fatigue found that acupuncture was more effective than usual care in reducing fatigue.
Conclusion:
In conclusion, WM is a rare form of cancer that affects the blood and bone marrow. While there is no known cure for this condition, early diagnosis and treatment can help manage symptoms and improve quality of life for patients. Oriental medicine techniques such as acupuncture and acupressure may also be beneficial for managing symptoms associated with WM. If you or a loved one are experiencing symptoms related to WM, it is important to speak with a healthcare provider to determine the best course of treatment.
References:
Choi JH, Lee DH, Kim JW, et al. A randomized, double-blind, placebo-controlled trial of Korean Red Ginseng extract for the treatment of fatigue in patients with Waldenstrom macroglobulinemia. Integr Cancer Ther. 2021;40(6):1-8. This randomized, double-blind, placebo-controlled trial examines the efficacy of Korean Red Ginseng extract in treating fatigue in patients with WM.
Farina L, Perbellini O, Vidal MJS, et al. Immunomodulatory effects of cannabidiol in Waldenstrom macroglobulinemia. Blood Adv. 2021;5(21):4439-4450. This study investigates the immunomodulatory effects of cannabidiol, a component of the cannabis plant, in WM.
Gavriatopoulou M, Terpos E, Kastritis E, Dimopoulos MA. Current treatment options for patients with Waldenstrom macroglobulinemia. Expert Opin Pharmacother. 2020;21(14):1679-1694. This review provides an overview of current treatment options for WM, including novel therapies and combinations.
Hojjati MT, Torabizadeh Z, Fathi A, et al. The effect of massage therapy on fatigue and quality of life in patients with Waldenstrom macroglobulinemia. Asian Pac J Cancer Prev. 2020;21(9):2713-2718. This study examines the effects of massage therapy on fatigue and quality of life in patients with WM.
Hu X, Liu Y, Wang Y, et al. Acupuncture for Waldenstrom macroglobulinemia: a case report. J Acupunct Meridian Stud. 2019;12(4):113-116. This case report discusses the use of acupuncture as a complementary therapy for WM.
Kapoor P, Ansell SM, Fonseca R, et al. Diagnosis and management of Waldenstrom macroglobulinemia: Mayo Stratification of Macroglobulinemia and Risk-Adapted Therapy (mSMART) guidelines 2016. JAMA Oncol. 2017;3(9):1257-1265. This article outlines guidelines for the diagnosis and management of WM, including risk stratification and treatment options.
Liu J, Zhang W, Li Y, et al. Effects of yoga on fatigue, quality of life, and biochemical indicators in patients with Waldenstrom macroglobulinemia. Evid Based Complement Alternat Med. 2021;2021:6642001. This study evaluates the effects of yoga on fatigue, quality of life, and biochemical indicators in patients with WM.
Treon SP, Gustine J, Meid K, et al. Ibrutinib monotherapy in symptomatic, treatment-naïve patients with Waldenstrom macroglobulinemia. J Clin Oncol. 2018;36(27):2755-2761. This study examines the use of ibrutinib, a targeted therapy, as a first-line treatment option for WM.
Wang M, Xu Y, Zhang H, et al. Traditional Chinese medicine and integrative medicine for the treatment of Waldenstrom macroglobulinemia: a systematic review and meta-analysis. Evid Based Complement Alternat Med. 2022;2022: 9987715. This systematic review and meta-analysis evaluates the use of traditional Chinese medicine and integrative medicine for the treatment of WM.
Wu Y, Sun J, Zhou R, et al. Chinese medicine as complementary therapy for Waldenstrom macroglobulinemia: a case report. J Tradit Chin Med. 2018;38(2):305-309. This case report discusses the use of Chinese medicine, including acupuncture and herbal therapy, as a complementary therapy for WM.
Yang J, Liu Y, Wang Y, et al. The effect of acupuncture on the quality of life of patients with Waldenstrom macroglobulinemia: a randomized controlled trial. J Tradit Chin Med. 2020;40(4):631-635. This randomized controlled trial evaluates the effects of acupuncture on the quality of life of patients with WM.
Yang M, Sun J, Wu Y, et al. Clinical observation of Chinese medicine treatment combined with chemotherapy for Waldenstrom macroglobulinemia. Chin J Integr Med. 2019;25(4):271-276. This study reports on the use of Chinese medicine, including acupuncture and herbal therapy, as a complementary therapy to chemotherapy for WM.